British Journal of Nursing, Vol. 21, Iss. Sup7, 23 May 2012, pp S16 - S17
Myeloma is a cancer of plasma cells that accumulate in the bone marrow. Plasma cells are mature B-lymphocytes that are capable of producing antibody. In myeloma, a plasma cell that has undergone malignant transformation is capable of producing a single antibody in an uncontrolled manner, at levels that are related to the number of malignant plasma cells. This is the basis of the serum paraprotein, a diagnostic test and marker of myeloma burden and response to therapy.